OUR IMPACT

Neurobiology of Disease Journal


Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury.

Can a nerve injury trigger ALS?


A growing collection of anecdotal stories raises the possibility that nerve injury in an arm or a leg can act as a trigger for the development amyotrophic lateral sclerosis, or ALS—a progressive neurodegenerative disease also known as Lou Gehrig's disease, named after the famous New York Yankee who died of it in 1941.

Studies We've Supported

Advancing an Animal model, developing human biomarkers, and validating a new drug to block the spread of ALS after a focal injury


Lead Research: Sarah Schram, Fei Song, and Jeffrey Loeb

University of Illinois, Chicago – October, 2019

A human in vitro model of ALS pathology induced by trauma in a genetically susceptible individual


Lead Research: John Finan, Evangelos Kiskinis

University of Illinois, Chicago – May, 2018

Combining Genetics with Environmental Injury in a new ALS Preclinical Model


Lead Research: Sarah Schram, Fei Song, and Jeffrey Loeb

University of Illinois, Chicago – August, 2017

Les Turner - General funding of clinical support services and research labs


Northwestern University & Les Turner Foundation