OUR IMPACT
Neurobiology of Disease Journal
Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury.
Can a nerve injury trigger ALS?
A growing collection of anecdotal stories raises the possibility that nerve injury in an arm or a leg can act as a trigger for the development amyotrophic lateral sclerosis, or ALS—a progressive neurodegenerative disease also known as Lou Gehrig's disease, named after the famous New York Yankee who died of it in 1941.
Studies We've Supported
Advancing an Animal model, developing human biomarkers, and validating a new drug to block the spread of ALS after a focal injury
Lead Research: Sarah Schram, Fei Song, and Jeffrey Loeb
University of Illinois, Chicago – October, 2019
A human in vitro model of ALS pathology induced by trauma in a genetically susceptible individual
Lead Research: John Finan, Evangelos Kiskinis
University of Illinois, Chicago – May, 2018
Combining Genetics with Environmental Injury in a new ALS Preclinical Model
Lead Research: Sarah Schram, Fei Song, and Jeffrey Loeb
University of Illinois, Chicago – August, 2017
Les Turner - General funding of clinical support services and research labs
Northwestern University & Les Turner Foundation